In normal digestion, the lower esophageal sphincter (LES) opens to allow food to pass into the stomach and closes to prevent food and acidic stomach juices from flowing back into the esophagus. Gastroesophageal reflux occurs when the LES is weak or relaxes inappropriately, allowing the stomach’s contents to flow up into the esophagus. This may causeĀ heartburn, regurgitation, chest pain, and other symptoms.

Impleo’s bulking agent is designed to restore LES closure, preventing or reducing the flow of gastric acid into the esophagus.